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FDA ( U.S. Food and Drug Administration ) approved Prograf ( Tacrolimus ), a drug for the prevention of graft rejection in the recipients of heart transplants.

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The present invention relates to improved fermentation processes for the preparation of tacrolimus or a salt or derivative thereof by culturing a microorganism.

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tical) was started with its dose adjusted for a target whole-blood trough level of 5 ng/mL. W ithin 2 weeks after the start of tacrolimus, she experienced a signif -.

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